• Hypersensitivity to Cannabinoids
• Cardiovascular Diseases including:
• • Arrhythmia
  • Heart failure (any kind)
  • Poorly regulated Hypertension
  • Ischemic heart disease
• History of Psychotic Disorders
  
• • (Schizophrenia, Schizoaffective)
• Family History of Psychotic Disorders
• History of Drug Abuse
• Family history of Drug Abuse
• Males intending to start a family
• Children less than 18 years old
• Pregnant or breast feeding females                  
  

Serious Risks:   

• Severe Psychiatric Side effects
• • Psychosis
  • Anxiety
  • Mood Disorder
• CNS Depression
• • Decreased Cognitive Performance
  • Impairs Short Term Memory
  • Impairs Attention, Coordination and Balance
  • Impairs Judgment
  • Impairs motor skills.
  • IMPAIRED DRIVING
• Tachycardia
• Drug Abuse Potential
• Hepatic Dysfunction – Transaminitis

Interactions:

• CNS Depressants adverse effects are enchanced
• Anticholinergics increase tachycardia with marijuana
• Cocaine worsens tachycardia with marijuana
• Sympathomimetics can worsen tachycardia with marijuana

Adapted from:

• NIDA Research Report Series Marijuana Abuse. NIH. Pub# 10-3859
• Handbook of the Medical Consequences of Alcohol and DrugAbuse / John Brick, editor.-2nd ed. p. cm. And referenced articles
• Smith,PF, “GW-1000. GW Pharmaceuticals, “Curr Opin Investig Drugs, 2004, 5(7):748-54 {PubMed 15298072]. Author: Michael Dekker, D.O.

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